Bruker Spatial Biology Center of Excellence
Spatial Platforms
nCounter Bulk Assays
nCounter Prep Station
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GeoMx
Overview
The GeoMx Digital Spatial Profiler enables high-plex spatial profiling of RNA and protein from user-defined regions of interest (ROIs) in FFPE and fresh frozen tissue. Our center specializes in neurodegenerative disease applications and high-plex protein assays.
Capabilities
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Whole Transcriptome Atlas (WTA) RNA profiling
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High-plex protein panels (including ~1200-plex Discovery Protein Atlas)
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ROI-based spatial resolution (custom morphology-guided selection)
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Multiomic RNA + protein co-profiling
Tissue Requirements
1. Ensure your tissue sample fits inside the Scan Area of the slide (green, in diagram below). Tissue may not overlap gasket (blue) or tip calibration area (red). Measure from label end of slide as reference point. Important: If the tissue sample is outside of this area, the GeoMx will not process the slide.
CosMx
Overview
CosMx Spatial Molecular Imager provides true single-cell and subcellular spatial resolution for RNA and protein detection, enabling deep characterization of cellular states and interactions in tissue.
Capabilities
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Single-cell and subcellular RNA detection (WTA or targeted panels)
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Integrated protein detection (e.g., Neuro 64 panel)
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Cell segmentation and spatial mapping
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High-content imaging across large tissue areas
What we do differently
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Rare multiomic datasets in human brain (RNA + protein at single-cell level)
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Integration with downstream spatial and 3D analysis tools
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Experience with complex neurodegenerative pathology
Tissue Requirements
Tissue sections must be centered within the Scan Area (the
green area) of the slide and be no larger than 20 mm Long by
15 mm Wide
CellScape
Overview
CellScape enables high-plex immunofluorescence imaging for spatial protein analysis across whole tissue sections, providing critical morphological context for downstream spatial profiling.
Capabilities
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Multiplex immunofluorescence (40+ protein targets)
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Whole-slide imaging with high resolution
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Large-scale tissue mapping
What we do differently
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Direct integration with GeoMx workflows
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Custom panel design for neurodegeneration
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High-throughput imaging across large cohorts
Typical use cases
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Tissue architecture mapping
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ROI pre-selection for spatial profiling
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Protein localization studies
Tissue Requirements
Prepare tissue sections with a thickness of 7-10 µm using a cryomicrotome.. Place the section onto a standard microscope slide in the area indicated by Figure 1. ​
PaintScape
coming soon
Overview
PaintScape is a high-precision spatial genomics platform for multiplexed, direct visualization of the 3D genome in situ at the single-cell level. It is designed to reveal chromosomal organization and genome architecture within intact cells and tissue, opening new opportunities to study how structural genome variation contributes to disease.
Capabilities
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Direct visualization of genome organization and chromosomal structure in single cells
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Multiplexed analysis of 3D genome architecture in situ
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Applications in cell lines
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Support for studying structural variation, chromatin organization, and genome dysregulation in disease contexts
Typical Use Cases
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Studying genome organization in disease
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Investigating chromosomal architecture in single cells
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Exploring structural genome variation linked to gene dysregulation
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Research into chromatin folding, interchromosomal interactions, copy-number-related architecture, and related mechanisms of disease
Contact
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